Nitric oxide synthase stimulates the production of nitric oxide, which, if produced excessively, can react with other molecules and create free radicals that trigger tissue damage in the kidneys (Pacher et al. 2007; Szalay et al. 2015). Tirapelli and colleagues (2012) showed that ethanol consumption increased the expression of two how does alcohol affect the kidneys nitric oxide synthases. However, it is still unclear exactly how ethanol upregulates nitric oxide synthases, or whether it does so directly or indirectly. It may be that toxins released from the intestines into blood circulation because of ethanol’s effects on the digestive system activate the expression of nitric oxide synthase.

  • One possible mechanism is oxidative stress resulting from increased production of reactive oxygen species, which leads to an excessive amount of free radicals, which in turn trigger tissue injury and increase inflammation.
  • At first, you might not have any symptoms of kidney damage from regular alcohol consumption.
  • Because scar tissue builds up and replaces most of the liver cells, it’s irreversible.
  • “Some people think of the effects of alcohol as only something to be worried about if you’re living with alcohol use disorder, which was formerly called alcoholism,” Dr. Sengupta says.

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  • You’ll only be considered for a liver transplant if you have developed complications of cirrhosis despite having stopped drinking.
  • Nitric oxide synthase stimulates the production of nitric oxide, which, if produced excessively, can react with other molecules and create free radicals that trigger tissue damage in the kidneys (Pacher et al. 2007; Szalay et al. 2015).
  • These changes can be profound in chronic alcoholic patients, who may demonstrate clinical evidence of dehydration.
  • You may have kidney pain after drinking alcohol due to dehydration or inflammation of your stomach lining.
  • This can cause mood or personality changes, impaired thinking, loss of concentration, and sleep problems.

While the liver can often repair itself after a period of alcohol use, the chronic, heavy consumption of alcohol can lead to permanent damage and the onset of cirrhosis, in which the liver is less able to filter blood. This, in turn, increases the risk of liver failure and liver cancer. Chronic or acute heart failure can lead to chronic or acute dysfunction in the kidneys, known as cardiorenal syndrome (Cleland et al. 2012).

what does alcohol do to your liver and kidneys

What Does Alcohol Do to Your Body? 9 Ways Alcohol Affects Your Health

Acute kidney injury usually goes away in time, but in some cases, it can lead to lasting kidney damage. As noted above, there is much to learn about alcoholic kidney disease and the complex interplay among multiple organs affected by alcohol consumption. Although research suggests several potential mechanisms by which alcohol may directly or indirectly affect the kidneys, they have not yet been validated experimentally. Future research will hopefully explore these hypotheses to provide a better understanding of alcoholic kidney injury. This article highlights the effects of other organs on kidney and renal function; however, it should be noted that alcoholic kidney injury itself may have negative metabolic consequences.

what does alcohol do to your liver and kidneys

Impaired Fluid Handling

That said, epidemiological data have yet to confirm a relationship between alcohol consumption and chronic kidney disease. A recent meta-analysis (Cheungpasitporn et al. 2015) found little support for such a relationship. Their analysis included 20 studies representing a total of 292,431 patients. In general, excessive alcohol consumption leads to liver damage [29]. However, some studies have found that ethanol can directly cause kidney damage, independent of liver damage [28,30,31].

Melatonin and chronic ethanol consumption: effects on the offspring liver and kidney – Revista Científica Multidisciplinar Núcleo do Conhecimento

Melatonin and chronic ethanol consumption: effects on the offspring liver and kidney.

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Association of monthly frequency of alcohol consumption and binge drinking with change in the eGFR over 12 years

  • However, if the person drinks alcohol again heavily, the fatty deposits will reappear.
  • Alcohol may also indirectly increase your risk of developing a UTI, which can cause kidney or abdominal pain.
  • Laube and colleagues (1967) suggested that both cellular enlargement and cell proliferation contribute to such nephromegaly.
  • In addition, alcohol can disrupt the hormonal control mechanisms that govern kidney function.
  • Furthermore, drinkers often like to eat more pickled food and eat less vegetables and fruits, which increases the consumption of salt and cholesterol [119].

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what does alcohol do to your liver and kidneys

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